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| HOURS |
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| 8:00AM - 5:00PM |
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Pilot Research Studies
Funded Projects
Current Awards
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Michael Chao, Department of Biology,
A novel approach to neuron-specific mRNA enrichment in C. elegans.
The long range goal of Dr. Chao's research is to understand the molecular and cellular mechanisms that regulate nervous system function. Through a fundamental understanding of these mechanisms, he hopes to develop new approaches towards therapies for mental and behavioral disorders in humans. The proposed studies contained herein address the development of a novel molecular tool for studying neuron function in the model organism C. elegans. This tool may also be adapted for use academically and/or commercially in other systems. Once this technology is established, functional studies to actually address the biology underlying nervous system function in C. elegans can be addressed, and will be focus of future grant proposals to the NIH and other federal granting agencies. |
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Kristy Dean, Department of Psychology,
Biculturalism and the health benefits of social flexibility
Dr. Dean's pilot studies are a product of a larger program of research based on the assertion that as an individual becomes adept at navigating distinct cultural situations, they are acquiring skills that assist them when navigating distinct interpersonal situations that are culturally universal. Like ongoing and future projects, the proposed studies emphasize the functionality of social flexibility: the aim of the proposed studies is to explore whether such social flexibility is a resiliency factor in the development of psychological and physical health problems. Although existing research on social competence supports this proposition, measurements of social flexibility specifically are lacking. Current measures rely on respondents' self-reported flexibility, and are thus open to personal bias (Riggio, 1986). Current measures do not directly assess the social-appropriateness of behavioral responses across situations, and thus are lacking in realism (Paulhus & Martin, 1988). As such, Dr. Dean has created a measure of social flexibility that she believes will resolve these oversights. The current studies offer preliminary insight into this issue, however future work can test methods to foster social flexibility and subsequently enhance health in immigrants and ethnic minorities. Thus, the proposed studies are a first step in demonstrating the functionality of social flexibility. The proposed external grant opportunity will allow for further development of this objective by furthering the development of the social flexibility construct.
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Keith Schubert, Department of Computer Science
Parallelizing pCT Image Reconstruction
Dr. Schubert, in collaboration with Dr. Reinhard Schulte of LLUMC, began the theoretical basis for image reconstruction of a new medical imaging modality called pCT (proton computed tomography) 9 months ago. Current imaging modalities (MRI, CT), while useful for certain parts of diagnosis, cannot map the electron density of the brain needed to improve the accuracy of proton therapy. The new imaging modality being developed would use protons to image the electron density of the brain, thus giving a precise description need to make proton therapy more accurate.
Dr. Schubert expects the theoretical work to be finished by this summer and will need to begin performance testing and tuning the reconstruction algorithm. A high performance graphics processor will be built using a desktop system with multiple graphics processors for a fraction of the cost of traditional supercomputers. The algorithms will be parallelized and programmed to run on the graphics cards, to reconstruct the image of a target from approximately 9 million protons passed through the target. Performance increase of reconstruction algorithm will be compared without graphics processors, with a single graphics processor, and with two graphics processors. This research study will solve the final problem before a prototype pCT imager can be designed and built, that being the computer requirements. |
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